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Chemoreceptors in the blood are specialized sensory receptors that play a crucial role in the regulation of respiratory function and the homeostasis of blood gases. They are primarily responsive to changes in pH, partial pressure of carbon dioxide (PCO2), and partial pressure of oxygen (PO2).

The pH level in the blood is influenced by the concentration of carbon dioxide; an increase in carbon dioxide results in an increase in hydrogen ions, consequently lowering pH. Thus, the chemoreceptors can detect this change, prompting a respiratory response to restore normal pH levels.

Similarly, these receptors respond to PCO2 levels in the blood. Elevated carbon dioxide indicates hypoventilation or respiratory issues, leading the body to adjust ventilation rates to expel excess CO2 and correct any respiratory acidosis.

Lastly, the response to PO2 is essential to ensure that oxygen levels remain within a viable range to meet metabolic demands. A significant decrease in PO2 will stimulate an increase in breathing rate to enhance oxygen intake, which is particularly crucial during situations like hypoxia.

In summary, the combination of these three parameters—pH, PCO2, and PO2—makes the correct answer. Each of these factors contributes significantly to the overall function of che